Domino's Pepperoni Pizza (1 slice): 295 calories
- 11gProtein
- 33gCarbs
- 12gFat
- 665mgSodium
Add it to an order in the calculator
Official U.S. values from Domino's Nutrition Guide (U.S., August 2026), last checked September 26, 2026. Restaurants change recipes, so values in your area can differ.
Domino's Pepperoni Pizza nutrition facts
| Item | Calories | Protein | Carbs | Fat | Sodium | % of 2,000 cal |
|---|---|---|---|---|---|---|
| Pepperoni Pizza (1 slice) | 295 | 11g | 33g | 12g | 665mg | 15% |
The Domino's Pepperoni Pizza (1 slice) is about 15% of a 2,000-calorie day and 29% of the 2,300mg daily sodium limit in the U.S. Dietary Guidelines.
How to make a Domino's order lighter
- Order the Cheese Pizza (1 slice) instead: 10 fewer calories, 11g protein.
- “Italian Sausage (topping, 1/8 pizza)” adds 70 calories.
- “Bacon (topping, 1/8 pizza)” adds 70 calories.
- “Mushrooms (topping, 1/8 pizza)” adds 5 calories.
- “Onions (topping, 1/8 pizza)” adds 5 calories.
How long it takes to burn off
For a 155 lb person, the Domino's Pepperoni Pizza (1 slice) takes about 67 minutes of brisk walking, 31 minutes of running (5 mph) or 31 minutes of cycling. Figures from Harvard Health’s calories-burned table; heavier people burn calories faster.
Compared with other restaurants
The closest item of the same kind at other chains:
- Pizza Hut Meat Lover's Pizza, Medium Original Pan (1 slice): 310 calories, 13g protein
- Taco Bell Mexican Pizza: 530 calories, 19g protein
Questions people ask
The Domino's Pepperoni Pizza (1 slice) has 295 calories, with 11g of protein, 33g of carbs and 12g of fat, according to the restaurant’s official U.S. nutrition information.
The Cheese Pizza (1 slice) has 285 calories, 10 fewer, and still keeps most of the protein.
More Domino's calories
Cheese Pizza · The People's Pizza – Deluxe · ExtravaganZZa · Ultimate Pepperoni · MeatZZa · Honolulu Hawaiian · Memphis BBQ Chicken · Pacific Veggie · Philly Cheese Steak · Spicy Chicken Bacon Ranch · Spinach & Feta · Wisconsin 6 Cheese · Cheese Pizza, Crunchy Thin · Stuffed Cheesy Bread · Garlic Bread Bites · Plain Wings, no sauce · Hot Buffalo Wings · Chocolate Lava Cake · Cinnamon Bread Bites